Decline in tuberculosis with 19 years of universal directly observed therapy in a comprehensive statewide program

作者：Webb R M^*; Penman A; Holcombe M; Dobbs T; Mathew T A

来源：International Journal of Tuberculosis and Lung Disease, 2011, 15(6): 848-850.

DOI：10.5588/ijtld.10.0381

• DOT
• TB treatment
• rural TB program

The Mississippi State Department of Health tuberculosis program serves a rural southeastern US state of 2.9 million people in an area of 121489 km(2) (46907 square miles). Statewide, directly observed therapy (DOT) began in 1986. To evaluate the program's effectiveness, trends in Centers for Disease Prevention and Control program indicators for 1981-2005 were compared and found to be significant (P < 0.0001). Inclusion of rifampin and pyrazinamide in the regimens was reviewed. An annual decline in cases and case rates began in 1990, falling by 65% by 2005. Successful DOT is feasible over a large geographic area.

• 出版日期2011-6