Antimicrobial activity of polyurethane embedded with methylene blue, toluidene blue and gold nanoparticles against Staphylococcus aureus; illuminated with white light

作者：Naik Anupriya J T; Ismail Salim; Kay Christopher; Wilson Michael; Parkin Ivan P^*

来源：Materials Chemistry and Physics, 2011, 129(1-2): 446-450.

DOI：10.1016/j.matchemphys.2011.04.040

• Polymer
• Biomaterial
• Antimicrobial
• Methylene blue
• Toluidene blue
• Nanogold

Polyurethane polymer sheets were embedded with methylene blue (MB), toluidine blue (TBO) and 2 nm gold nanoparticles by a swell-shrink encapsulation process using an acetone water mixture. The polymers were characterised by IR, UV-vis, SEM/WDX and mechanical testing. The dye impregnated polymers were potent at killing suspensions of Staphylococcus aureus under white illumination with a hospital light source (2000 lux) showing a 2.8 log(10) kill (MB) and a 4.3 log(10) kill (TBO) compared to controls when exposed to 24 h of illumination. Notably the incorporation of gold nanoparticles with the dyes enhanced the observed kill to 3.8 log(10) (MB) and 4.8 log(10) (TBO). This is the first time that a derivatised polyurethane polymer used in catheters has been shown to be effective in killing bacteria using white light illumination.

• 出版日期2011-9-15