A histologic study of deformation of the mandibular condyle caused by distraction in a rat model

作者：Sakagami Naoko^*; Kobayashi Tadaharu; Nozawa Inoue Kayoko; Oda Kimimitsu; Kojima Taku; Maeda Takeyasu; Saito Chikara

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2014, 118(3): 284-294.

DOI：10.1016/j.0000.2014.05.003

Objective. This study investigated the bone resorption process of the rat mandibular condyle after mandibular distraction. %26lt;br%26gt;Study Design. Male Wistar rats at 10 weeks of age underwent unilateral mandibular distraction at 0.175 mm per 12 hours for 10 days. Histologic and histochemical analyses were performed at postoperative day 1 and weeks 1 and 3. %26lt;br%26gt;Results. High-resolution computed tomography (micro-CT) observations showed that deformation of the condyle occurred in the anterior region, where a discontinuity of the condylar cartilage layer was found in histologic sections. This destroyed area gathered many osteoclasts. In the central region, disorganization with a thin hypertrophic cell layer was recognizable by day 1 but later thickened. Morphologic recovery of the mandibular condyle could be attained by week 3 in this animal model. %26lt;br%26gt;Conclusions. These morphologic findings indicate that rapid deformation of the condyle, with destruction of the cartilage layer and bone resorption, was caused by artificial distraction.

• 出版日期2014-9