Microglial TNF-alpha Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

作者：Lewitus Gil M; Konefal Sarah C; Greenhalgh Andrew D; Pribiag Horia; Augereau Keanan; Stellwagen David

来源：Neuron, 2016, 90(3): 483-491.

DOI：10.1016/j.neuron.2016.03.030

Repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc) through an unknown mechanism. Furthermore, glial cells in the NAc are activated by drugs of abuse, but the contribution of glia to the development of addictive behaviors is unknown. Tumor necrosis factor alpha (TNF-alpha), an inflammatory cytokine released by activated glia, can drive the internalization of synaptic AMPA receptors on striatal medium spiny neurons. Here we show that repeated administration of cocaine activates striatal microglia and induces TNF-alpha production, which in turn depresses glutamatergic synaptic strength in the NAc core and limits the development of behavioral sensitization. Critically, following a period of abstinence, a weak TLR4 agonist can reactivate microglia, increase TNF-alpha production, depress striatal synaptic strength, and suppress cocaine-induced sensitization. Thus, cytokine signaling from microglia can regulate both the induction and expression of drug-induced behaviors.

• 出版日期2016-5-4