A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort

作者：Braun Katharina; Sjoberg Daniel D; Vickers Andrew J; Lilja Hans; Bjartell Anders S

来源：European Urology, 2016, 69(3): 505-511.

DOI：10.1016/j.eururo.2015.04.028

• Prostate-specific antigen
• Biopsy
• Four-kallikrein panel
• Prostate cancer

Background: A statistical model based on four kallikrein markers (total prostate-specific antigen [tPSA], free PSA [fPSA], intact PSA, and human kallikrein-related peptidase 2) in blood can predict risk of Gleason score >= 7 (high-grade) cancer at prostate biopsy.
Objective: To determine the value of this model in predicting high-grade cancer at biopsy in a community-based setting in which referral criteria included percentage of fPSA to tPSA (%fPSA).
Design, setting, and participants: We evaluated the model, with or without adding blood levels of microseminoprotein-beta (MSMB) in a cohort of 749 men referred for prostate biopsy due to elevated PSA (>= 3 ng/ml), low %fPSA (<20%), or suspicious digital rectal examination at Skane University Hospital, Malmo, Sweden.
Outcome measurements and statistical analysis: The kallikrein markers, with or without MSMB levels, measured in cryopreserved anticoagulated blood were combined with age in a published statistical model (Prostate Testing for Cancer and Treatment [ProtecT]) to predict high-grade cancer at biopsy. Predictive accuracy was compared with a base model.
Results and limitations: The %fPSA was low (median: 17; interquartile range: 13-22) in this cohort because this marker was used as a referral criterion. The ProtecT model improved discrimination over age and PSA for high-grade cancer (0.777 vs 0.720; p = 0.002). At one illustrative cut point, use of the panel would reduce the number of biopsies by 236 per 1000 and detect 195 of 208 (94%) but delay diagnosis of 13 of 208 high-grade cancers. MSMB levels in blood did not improve the accuracy of the panel (p = 0.2).
Conclusions: The kallikrein model is predictive of high-grade cancer if criteria for biopsy referral also include %fPSA, and it can reduce unnecessary biopsies without missing an undue number of tumors.
Patient summary: We evaluated a published model to predict biopsy outcome in men biopsied due to low percentage of free to total prostate-specific antigen. The model helps reduce unnecessary biopsies without missing an undue number of high-grade cancers.

• 出版日期2016-3