Anti-influenza diarylheptanoids from the bark of Alnus japonica

作者：Tung Nguyen Huu; Kwon Hyuk Joon; Kim Jae Hong; Ra Jeong Chan; Ding Yan; Kim Jeong Ah; Kim Young Ho^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(3): 1000-1003.

DOI：10.1016/j.bmcl.2009.12.057

• Alnus japonica
• Betulaceae
• Diarylheptanoid
• Anti-influenza
• KBNP-0028 (H9N2)

This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.

• 出版日期2010-2-1