Aquaporin-4 autoimmunity masquerading as a brainstem tumor

作者:Lim Byung Chan; Chae Jong Hee; Kim Seung Ki; Park Sung Hye; Wang Kyu Chang; Lee Ji Yeoun; Phi Ji Hoon*
来源:Journal of Neurosurgery-Pediatrics, 2014, 14(3): 301-305.
DOI:10.3171/2014.6.PEDS13674

摘要

Brainstem glioma is a highly devastating disease, and any mass-like lesion in the brainstem can raise suspicion of this diagnosis. However, other inflammatory, demyelinating, or degenerative diseases can mimic brainstem glioma in clinical presentation and imaging features. Therefore, diagnosis based solely on imaging is often insufficient for brainstem lesions and may lead to incorrect diagnosis and treatment. This case report is the first description of central nervous system aquaporin-4 (AQP4) autoimmunity confined mainly to the brainstem. It demonstrates the wide spectrum of neuroinfiammatory diseases in children and highlights the utility of surgical biopsy for suspicious brainstem lesions with atypical imaging features for glioma.

  • 出版日期2014-9