The therapeutic effect of oral Channa striatus extract on primary knee osteoarthritis patients

作者：Kadir Azidah Abdul^*; Ab Wahab Siti Zubaidah; Zulkifli Maryam Mohd; Noor Norhayati Mohd; Baie Saringat Bin Bai; Haron Juhara

来源：Agro Food Industry Hi-Tech, 2014, 25(3): 44-48.

• channa striatus
• knee osteoarthritis
• pain
• symptom
• quality of life
• analgesic consumption

Channa striatus is a fresh water fish known as natural remedy for traditional medicine in Southeast Asian region. This is a randomized, double-blind, placebo-controlled trial comparing the effects of oral Channa striatus extract 500 mg/day with placebo given for 3-month intervention period among primary knee osteoarthritis patients. Eighty eight patients were randomly assigned to C. striatus and placebo group. The objectives were to compare pain, symptoms, activity of daily living, sports and quality of life between intervention and control group using Knee Injury and Osteoarthritis Outcome Score (KOOS). Analgesic consumption was also compared using analgesic score. %26lt;br%26gt;There were significant improvement of pain, symptoms and quality of life (QOL) domain score (p%26lt;0.05) in C. striatus group compared to patients who received placebo. There were no changes in safety profile parameters among the patients before and after treatment. In conclusion, the oral administration of Channa striatus extract would be a new alternative for knee osteoarthritis treatment.

• 出版日期2014-6