Association between interleukin-18 genetic polymorphisms and development of acute pancreatitis risk in a Chinese population

作者：Ye, Baning; Wang, Yuhui^*; Shi, Xianqing; Wang, Jinlong; Long, Dali; Li, Kun

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(9): 9387-9393.

• IL-18
• rs1946518
• rs187238
• polymorphism
• acute pancreatitis

Here, we conducted a case-control study to investigate the association between two promoter SNPs in IL-18, rs1946518 and rs187238 genetic variations and acute pancreatitis susceptibility in a Chinese population. This study comprised of 172 patients with acute pancreatitis and 236 control subjects. The IL-18 genotyping for rs1946518 and rs187238 polymorphic sites was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). As confirmed by chi-square tests, acute pancreatitis patients and healthy control subjects differed significantly in genotype frequencies at IL-18 rs187238 (X-2= 10.52, P= 0.005). The multiple logistic regression analysis revealed that the CC genotype of IL-18 rs187238 was significantly associated with the acute pancreatitis susceptibility in this population (adjusted OR= 3.01, 95% CI= 1.43-6.49), when compared with the healthy control subjects. Additionally, the C allele of IL-18 rs187238 was more significantly correlated with the risk of acute pancreatitis susceptibility as compared to the G allele (adjusted OR= 1.63, 95% CI= 1.19-2.23). However, no significant relationship was observed between IL-18 rs1946518 and risk of acute pancreatitis susceptibility. In conclusion, we suggested that the IL-18 rs187238 gene polymorphisms may influence the susceptibility to acute pancreatitis in a Chinese population.

• 出版日期2016
• 单位贵州省人民医院