ACUTE PROGESTERONE TREATMENT IMPAIRS SPATIAL WORKING MEMORY IN INTACT MALE AND FEMALE RATS

作者：Sun Wei Lun; Luine Victoria N; Zhou Luyi; Wu Hui Bing; Weierstall Karen M; Jenab Shirzad; Quinones Jenab Vanya^*

来源：Ethnicity & Disease, 2010, 20(1): 83-87.

• Object Recognition
• Spatial Memory
• Non-spatial Memory
• Gender Differences
• Sex Differences

Introduction: The aim of this study was to determine if progesterone affects spatial and non-spatial working memory in intact male and female rats.
Methods: Rats received subcutaneous injections of progesterone (500 jig) or vehicle (sesame oil). Four hours after hormone treatments, spatial and non-spatial memories were tested using novel object recognition and spatial object recognition tasks.
Results: Vehicle-treated female rats had higher progesterone serum levels than males, but progesterone treatment produced equivalent progesterone serum levels in both sexes. In the object recognition task a non-spatial memory task females showed better performance than males, and progesterone had no effect on either sex. However, in the object replacement task a spatial memory task progesterone significantly impaired the retention in both male and female rats as compared with vehicle-treated groups.
Conclusion: These results suggest that acute progesterone treatment interferes with spatial working memory consolidation, but not recognition (non-spatial) working memory. As such, the observed sexual incongruities in progesterone's effects on working memory suggest that progesterone-based hormone therapies have a negative impact on cognition. (Ethn Dis. 2010;20[Suppl 1]:S1-83-S1-87)

• 出版日期2010