Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide

作者：Nodwell Matthew B; Bagai Abhimanyu; Halperin Shira D; Martin Rainer E; Knust Henner; Britton Robert^*

来源：Chemical Communications, 2015, 51(59): 11783-11786.

DOI：10.1039/c5cc04058b

The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of benzylic C-H bonds provides a means to attenuate drug metabolism at this metabolically labile position. Here we report two complimentary strategies for the direct fluorination of benzylic C-H bonds using N-fluorobenzenesulfonimide and either a decatungstate photocatalyst or AIBN-initiation.

• 出版日期2015