Glycopentaphyllone: The first isolation of hydroperoxyquinolone from the fruits of Glycosmis pentaphylla

作者：Sripisut Tawanun; Ritthiwigrom Thunwadee; Promgool Trinop; Yossathera Kulsiri; Deachathai Suwanna; Phakhodee Wong; Cheenpracha Sarot; Laphookhieo Surat^*

来源：Phytochemistry Letters, 2012, 5(2): 379-381.

DOI：10.1016/j.phytol.2012.03.007

• Glycosmis pentaphylla
• Rutaceae
• Hydroperoxyquinolone
• Quinolone alkaloids
• Antibacterial activity

A new hydroperoxyquinolone alkaloid, glycopentaphyllone (1), along with nine compounds (2-10), was isolated from the fruits of Glycosmis pentaphylla. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of glycopentaphyllone at C-2%26apos; was established as S-configuration by applying Mosher%26apos;s method. In addition, the completed assignments of C-13 NMR as well as 2D NMR spectral data of compound 5 were reported herein for the first time. Also, all isolates were evaluated for antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466, and Methicillin-resistant S. aureus SK1.

• 出版日期2012-6