科研之友
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摘要
It has been shown on the examples of paracetamol, ibuprofen, and salbutamol that the use of mixed water-organic solvents, which are capable of clathrate formation, enables one to obtain high-disperse drug powders that are weakly soluble in water via sublimation drying of frozen solutions. The prepared powders are applicable for direct compression to pellets, have a higher rate of passing into solution for drug compared to initial substances, and can be used to prepare the suspensions for children's preparations and dosage forms as freon-free aerosols for pulmonary administration.
- 出版日期2014-9
