Potent anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R. Br. ex Cass., a Q%26apos;eqchi%26apos; Maya traditional medicine

作者：Walshe Roussel Brendan; Choueiri Christine; Saleem Ammar; Asim Muhammd; Caal Federico; Cal Victor; Otarola Rojas Marco; Pesek Todd; Durst Tony; Arnason John Thor^*

来源：Phytochemistry, 2013, 92: 122-127.

DOI：10.1016/j.phytochem.2013.05.004

• Neurolaena lobata
• Asteraceae
• Sesquiterpene lactones
• Neurolenin
• Lobatin
• Parthenolide
• Anti-inflammatory
• TNF-alpha
• Traditional medicine

The widespread use of Neurolaena lobata (L.) R. Br. ex Cass. by Q%26apos;eqchi%26apos; Maya and indigenous healers throughout the Caribbean for inflammatory conditions prompted the study of the anti-inflammatory activity of this traditional medicine. The objectives of this study were to conduct a detailed ethnobotanical investigation of the uses of N. lobata by the Q%26apos;eqchi%26apos; Maya of Belize for a variety of inflammatory symptoms and to evaluate the in vitro anti-inflammatory activity of leaf extract and isolated sesquiterpene lactones. The crude 80% EtOH extract of N. lobata leaves administered at 100 mu g/mL reduced LPS-stimulated TNF-alpha, production in THP-1 monocytes by 72% relative to the stimulated vehicle control. Isolated sesquiterpene lactones, neurolenins B, C + D, lobatin B and 9 alpha-hydroxy-8 beta-isovalerianyloxy-calyculatolide were more active (IC50 = 0.17-2.32 mu M) than the positive control parthenolide (IC50 = 4.79 mu M). The results provide a pharmacological and phytochemical basis for the traditional use of this leaf for inflammatory conditions.

• 出版日期2013-8