A comparison of stochastic variation in mixed and unmixed casework and synthetic samples

作者：Bright Jo Anne^*; McManus Kurt; Harbison SallyAnn; Gill Peter; Buckleton John

来源：Forensic Science International-Genetics, 2012, 6(2): 180-184.

DOI：10.1016/j.fsigen.2011.04.010

• Mixed DNA profile
• Heterozygote balance
• Mixture proportion

Understanding the behaviour of mixed DNA profiles is of paramount importance in forensic DNA analysis. Key parameters are those of heterozygote balance and mixture proportion and its variability. These parameters have been previously explored as a function of the average peak height of the active alleles in single source and mixed samples derived from pristine DNA. Here we report a comparison of this data with data obtained from casework samples. This allows an assessment of the difference in the distribution of heterozygote balance between mixed and single source stains and between casework mixtures and synthetic mixtures constructed from pristine DNA.

• 出版日期2012-3