Mitochondria in response to nutrients and nutrient-sensitive pathways

作者：Baltzer Claudia; Tiefenbock Stefanie K; Frei Christian^*

来源：Mitochondrion, 2010, 10(6): 589-597.

DOI：10.1016/j.mito.2010.07.009

• Mitochondria
• Nutrients
• TCA cycle
• Oxidative phosphorylation
• Microarray

Mitochondria are abundant cellular organelles and are required for the generation of energy through oxidative catabolism Equally important mitochondria also provide substrates for de novo synthesis of fatty acids and multiple amino acids Mitochondrial functions must therefore be tightly linked to cellular nutrient availability This review focuses on the current knowledge of how nutrients affect mitochondria In particular we describe how the transcriptional profile of the nucleus is altered to mediate this control and the transcription factors that are Involved In addition we summarize recent progress in our understanding of how transcription-independent mechanisms most nota

• 出版日期2010-11