Chromatin states and nuclear organization in development - a view from the nuclear lamina

作者:Mattout Anna; Cabianca Daphne S; Gasser Susan M
来源:Genome Biology, 2015, 16(1): 174.
DOI:10.1186/s13059-015-0747-5

摘要

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.

  • 出版日期2015-8-25