Microwave-assisted synthesis of 3-substituted-6-ferrocene methylene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

作者：Liu, Yuting; Xin, Hong^*; Yin, Jingyi; Yin, Dawei

来源：Transition Metal Chemistry, 2018, 43(5): 381-385.

DOI：10.1007/s11243-018-0219-3

• SCHIFF-BASES
• PHARMACOLOGICAL EVALUATION
• CYTOTOXIC ACTIVITIES
• HETEROCYCLIC SYSTEM
• DERIVATIVES
• 1,2,4-TRIAZOLE
• ANTIBACTERIAL
• DESIGN
• ACID

A series of triazolo-thiadiazole derivatives containing ferrocene were synthesized under microwave assistance. Compared with the phosphorus oxychloride method, the microwave method has the advantages of simple operation, short reaction time, fast reaction rate and high yield. The effects of different reaction conditions were explored, and under the optimized conditions, the products were obtained in good yields (up to 80%).

• 单位
  陕西科技大学