Asymmetry of Dopamine D2/3 Receptor Availability in Dorsal Putamen and Body Mass Index in Non-obese Healthy Males

作者：Cho Sang Soo; Yoon Eun Jin; Kim Sang Eun^*

来源：Experimental Neurobiology, 2015, 24(1): 90-94.

DOI：10.5607/en.2015.24.1.90

• Dopamine
• striatum
• body mass index
• asymmetry

The dopaminergic system is involved in the regulation of food intake, which is crucial for the maintenance of body weight. We examined the relationship between striatal dopamine (DA) D2/3 receptor availability and body mass index (BMI) in 25 non-obese healthy male subjects using [11C] raclopride and positron emission tomography. None of [11C] raclopride binding potential (BP) values (measures of DA D2/3 receptor availability) in striatal subregions (dorsal caudate, dorsal putamen, and ventral striatum) in the left and right hemispheres was significantly correlated with BMI. However, there was a positive correlation between the right-left asymmetry index of [11C] raclopride BP in the dorsal putamen and BMI (r= 0.43, p< 0.05), suggesting that greater BMI is linked with higher receptor availability in the right dorsal putamen relative to the left in non-obese individuals. The present results, combined with previous findings, may also suggest neurochemical mechanisms underlying the regulation of food intake in non-obese individuals.

• 出版日期2015-3