科研之友
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摘要
A new compound, illiciumflavane acid (1), along with 13 known compounds (2-14), were isolated from the fruits of Illicium verum Hook. F. Their structures were elucidated through various spectroscopic methods, including 1D NMR (H-1 NMR, C-13 NMR), 2D NMR (HMQC, HMBC and NOESY) and HRMS. The stereochemistry at the chiral centres was determined using CD spectrum as well as analyses of coupling constants and optical rotation data. Cytotoxicity evaluation of four compounds showed that illiciumflavane acid and (E)-1,2-bis(4-methoxyphenyl) ethene exhibited potential against A549 activities with IC50 values of 4.63 mu M and 9.17 mu M, respectively. [GRAPHICS] The structure of a new compound isolated from the fruits of Illicium verum has been determined by detailed spectroscopic analyses. The cytotoxicity activities of four compounds were determined against P-388, NUGC, HT-29 and A549 cancer cell lines. Illiciumflavane acid (1) and (E)-1,2-bis(4-methoxyphenyl) ethene (5) showed activites against the four cell lines that were comparable to cisplatin.
- 出版日期2016
- 单位广西师范大学
