Determination of 48 pesticides and their main metabolites in water samples by employing sonication and liquid chromatography-tandem mass spectrometry

作者：Fenoll Jose^*; Hellin Pilar; Martinez Carmen M; Flores Pilar; Navarro Simon

来源：Talanta, 2011, 85(2): 975-982.

DOI：10.1016/j.talanta.2011.05.012

• Multiresidue
• Waters
• Metabolites
• Pesticides
• Liquid chromatography

In this work, a rapid and sensitive analytical multiresidue method has been developed for the simultaneous determination of 48 pesticides and 19 metabolites in waters (tap, leaching and sewage), using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with triple quadrupole in selected reaction monitoring (SRM) mode. The procedure involves initial single phase extraction of samples with acetonitrile by sonication, followed by liquid-liquid partition aided by "salting out" process using NaCl. Matrix influence on recoveries was evaluated for the three waters. More than 50% of the compound presented very low signal suppression. The method presents good linearity over the range assayed 10-500 mu g L(-1) and the most frequent detection limits was 0.05 ng mL(-1). The average recovery by the LC-MS/MS method obtained for these compounds varied from 74.6 to 111.2% with a relative standard deviation between 2.5 and 8.9%. The proposed method was used to determine pesticides levels in leaching water samples from 5 lysimeters from an experimental greenhouse located in Murcia.

• 出版日期2011-8-15