Microfluidic chip-based liquid chromatography coupled to mass spectrometry for determination of small molecules in bioanalytical applications: An update

作者：Lin Shu Ling; Lin Tzuen Yeuan; Fuh Ming Ren^*

来源：Electrophoresis, 2014, 35(9): 1275-1284.

DOI：10.1002/elps.201300415

• Bioanalytical applications
• Chip-based LC-MS
• MS
• MS

Many microfluidic chip-based LC-MS systems have been utilized for high-throughput analysis in various fields of bioanalytical applications such as proteomic, glycomic, pharmaceutical, and clinical research. This review is an update of a previous review article (Electrophoresis 2012, 33, 635-643) to mainly cover the most recent advancements in chip-based LC-MS for determining small molecules in bioanalysis. First, the different types of microfluidic chip devices for chip-based LC-MS analysis will be discussed. Following the discussion of the recent developments in the chip-based instrumentation, the applications of chip-based LC-MS for determining small molecules, such as glycans, pharmaceutical drugs, drugs of abuse, drug metabolites, and biomarkers in various biological sample matrixes will also be included in this review.

• 出版日期2014-5
• 单位苏州大学