A mass spectrometric investigation into microenvironmental effects in solid-supported radical chemistry

作者：Helliwell Philip Andrew; Bailey Victoria Adele; Chevet Caroline; Clarke Don Brian; Lloyd Antony; Macarthur Roy; Routledge Anne^*

来源：Reactive and Functional Polymers, 2010, 70(2): 110-115.

DOI：10.1016/j.reactfunctpolym.2009.10.012

• Radical reaction
• Solid-phase synthesis
• EPHP
• Mass spectrometry
• Deuterium labelling

Deuterated N-ethylpiperidine hypophosphite (d-EPHP) and tributyltin deuteride (TBTD) have been used to explore potential microenvironmental effects in resin-bound radical propagation. A deuterium labelling mass spectrometric method was used to show that efficiency of radical chain propagation on resin can be influenced by the choice of solid-support when using the slow radical chain carrier, EPHP.

• 出版日期2010-2