Anticancer activity of osmium metalla-rectangles

作者：Barry Nicolas P E; Edafe Fabio; Dyson Paul J; Therrien Bruno^*

来源：Dalton Transactions, 2010, 39(11): 2816-2820.

DOI：10.1039/b925015h

A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os(4)(OO boolean AND OO)(2)(N boolean AND N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os(2)(OO boolean AND OO)(2)Cl(2)] (OO boolean AND OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N boolean AND N = 4,4'-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF(3)SO(3). All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)(4)Os(4)(dhbq)(2)(4,4'-bipyridine)(2)](4+), shows an IC(50) value of 5.7 mu M (comparable to cisplatin) against A2780 cancer cells and 7.5 mu M against the cisplatin resistant A2780cisR cells.

• 出版日期2010