科研之友
微信
新浪微博
Facebook
分享链接
摘要
Autophagy is a conserved system for the degradation of cytoplasmic proteins and organelles. During insulin resistance, in which insulin secretion is enhanced and beta-cell mass is increased owing to changes in the expression and function of various proteins in pancreatic beta-cells, autophagic activity appears to also be enhanced to adapt to the dynamic changes occurring in beta-cells. Indeed, defective autophagy in beta-cells recapitulates several features that are observed in islets during the development of type 2 diabetes mellitus. In addition, the dyregulation of autophagic activity appears to occur in the beta-cells of type 2 diabetic model mice and type 2 diabetes mellitus patients. These lines of evidence suggest that autophagic failure may be implicated in the pathophysiology of type 2 diabetes mellitus. In this review, we summarized the recent findings regarding how autophagy in beta-cells is regulated and how dysfunction of the autophagic machinery may lead to the dysfunction of beta-cells.
- 出版日期2015-3
