科研之友
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摘要
Objectives. In order to reveal the etiology and pathophysiology of trichotillomania (TTM). It is necessary to investigate which brain regions are involved in TTM, but limited knowledge exists regarding the neurobiology of TTM and the available functional neuroimaging studies of TTM are little The purpose of the present study was to investigate the specific brain regions involved in the pathophysiology of TTM with symptom provocation task using functional magnetic resonance imaging (fMRI) for children and adolescents with TTM
Methods. Pediatric subjects who met the DSM-IV TR criteria for TTM (n = 9) and age-, sex-, handedness-, IQ matched healthy controls(HC) (n = 10), ages 9 to 17 years, were recruited for two fMRI experiments; symptom provocation of Visual Only (VU) and Visual and Tactile (VT). They were scanned while viewing two alternating blocks of symptom provocation (S) and neutral (N) movies
Results. Random effects between-group analysis revealed significant activation in left temporal cortex (Including middle and superior temporal gyrus), dorsal posterior ungulate gyrus, and putamen for the contrast S>N in TTM subjects versus HC subjects during the VU session. And TTM subjects demonstrated higher activity in the precuneus and dorsal posterior ungulate gyrus to the contrast S>N during the VT session.
Conclusions This study provided an objective whole-brain-based analysis that directed researchers to areas that were abnormal in TTM. Using the symptom provocation tasks, we found significant differences in regional brain function between pediatric TTM and HC subjects. However, in the face of modest statistical power, our preliminary findings in TTM need to be replicated in a larger sample As the functional neuroanatomic circuits involved in T
- 出版日期2010-10-1
