Analysis of Clinical Efficacy and Adverse Effects of beta-Blocking Agents Used Clinically for Chronic Heart Failure

作者：Takayanagi Risa; Fujito Kaori; Kimura Koji^*; Yamada Yasuhiko

来源：Biological & Pharmaceutical Bulletin, 2017, 40(6): 837-843.

DOI：10.1248/bpb.b16-00992

• beta-blocking agent
• chronic heart failure
• receptor occupancy
• ternary complex model

Clinical efficacy and adverse effects of the beta-blocking agents, carvedilol, bisoprolol, and metoprolol were analyzed theoretically, and then compared quantitatively, for the purpose of determining their proper use for chronic heart failure. Initially, we evaluated occupancy binding to the beta(1) and beta(2) receptors (Phi(beta 1)(SS) and Phi(beta 2)(SS)) by these drugs. Thereafter, we examined the relationship between (Phi(beta 1)(SS) values and left ventricular ejection fraction (LVEF) increase rate to determine efficacy. The result showed that the efficacy with carvedilol could be attained with a lower Phi(beta 1)(SS) value than the others. Therefore, we constructed a model under the assumption that beta-blocking agents exert both indirect action of LVEF increase through the beta(1) receptor and direct action on ryanodine receptor 2. Using the model, it was suggested that these drugs have no differences in regard to the efficacy, while it was clarified theoretically that only carvedilol produces an effect that directly involves ryanodine receptor 2 at clinical doses. We also investigated decreases in heart rate and forced expiratory volume in 1 s as adverse effects of beta-blocking agents using a ternary complex model. It was indicated that carvedilol is less likely to induce a heart rate decrease. Meanwhile, it was also suggested that the risk of an asthmatic attack was higher for carvedilol at clinical doses. Our results are considered useful for selection of a proper beta-blocking agent and its administration at a reasonable dose for successful heart failure therapy.

• 出版日期2017-6