Acetylation Unleashes Protein Demons of Dementia

作者：Mattson Mark P^*

来源：Neuron, 2010, 67(6): 900-902.

DOI：10.1016/j.neuron.2010.09.010

Aberrant posttranslational modifications of proteins can impair synaptic plasticity and may render neurons vulnerable to degeneration during aging. In this issue of Neuron, Min et al. show that acetylation of the amino acid lysine in the microtubule-associated protein tau prevents its ubiquitin-mediated degradation, resulting in "tau tangles" similar to those of dementias. Other recent studies suggest that lysine hyperacetylation contributes to the accumulation of amyloid beta-peptide in Alzheimer's disease and to impaired cognitive function resulting from a trophic factor deficit.

• 出版日期2010-9