Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis

作者：Zarifkar Asadollah; Choopani Samira; Ghasemi Rasoul; Naghdi Nasser; Maghsoudi Amir Hossein; Maghsoudi Nader; Rastegar Karim^*; Moosavi Maryam

来源：European Journal of Pharmacology, 2010, 634(1-3): 84-88.

DOI：10.1016/j.ejphar.2010.02.029

• LPS
• Agmatine
• Water maze
• Learning
• Apoptosis
• Rat

Neuroinflammation is associated with a number of neurodegenerative diseases. It is known that lipopolysaccharide (LPS) treatment induces neuroinflammation and memory deterioration. Agmatine, the metabolite of arginine by arginine decarboxylase, is suggested to be a neuroprotective agent. The aim of this study was to explore if agmatine can prevent LPS-induced spatial memory impairment and hippocampal apoptosis. Adult male Wistar rats (200-250 g) were trained in water maze for 4 days (3 days in hidden platform and the last day in visible platform task). Saline, LPS (250 mu g/kg/ip) or (and) agmatine (5 or 10 mg/kg) were administered 4 h before every training session. U'S treatment impaired water maze place learning while agmatine co-administration prevented it. Also western blot studies revealed that LPS induces hippocampal caspase-3 activation while agmatine treatment prevented it.

• 出版日期2010-5-25