Association of beta 2-microglobulin with the prognosis of non-Hodgkin's lymphoma: a meta analysis

作者：Wang, Xiao-Liang; Wang, Xiao-Li; He, Shuo; Zhai, Hong-Li^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(3): 3992-3999.

• beta 2-microglobulin
• non-Hodgkin's lymphoma
• meta-analysis

Objective: The influence of beta 2-microglobulin (beta 2-MG) on the prognosis of non-Hodgkin's lymphoma (NHL) remains controversial. This study performed meta-analyses to evaluate the prognostic value of beta 2-MG on the overall survival (OS) of NHL. Methods: Through a search of relevant literature in PubMed, EMbase, Science Direct, OVID and Wanfang databases from 1980-2013, the hazard ratios (HRs) of OS between the normal beta 2-MG group and the increased beta 2-MG group were retrieved, and the results were combined using a fixed effect model and a random effect model. Subgroup analyses were performed based on univariate and multivariate analysis results, and sensitivity analyses were performed to estimate the changes of the combined HRs. In addition, funnel plots and fail-safe numbers were used to estimate publication bias. Results: A total of 17 qualified publications were included, with a cumulative total of 2,479 cases. The result of heterogeneity examination showed that there was heterogeneity among all studies (P < 0.001, I-2 = 87%). In the random effect model, the combined HR was 2.71 (95% confidence interval [CI]: 1.91-3.85). The result of the total effect examination was statistically significant (Z = 5.59, P < 0.001). Conclusion: The increased beta 2-MG level was an independent risk factor for the prognosis of NHL.

• 出版日期2015
• 单位烟台毓璜顶医院; 青岛大学