A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast

作者：Wang Shaoxiao; Horn Patrick J; Liou Liang Chun; Muggeridge Martin I; Zhang Zhaojie; Chapman Kent D; Witt Stephan N^*

来源：Biochemical and Biophysical Research Communications, 2013, 438(2): 452-456.

DOI：10.1016/j.bbrc.2013.07.100

• Alpha-synuclein
• Lipid droplets
• Peroxisome
• Parkinson%26apos
• s disease

Using a yeast model of Parkinson%26apos;s disease, we found that alpha-synuclein (alpha S) binds to lipid droplets in lipid-loaded, wild-type yeast cells but not to lipid droplets in lipid-loaded, peroxisome-deficient cells (pex3 Delta). Our analysis revealed that pex3 Delta cells have both fewer lipid droplets and smaller lipid droplets than wild-type cells, and that the acyl chains of the phospholipids on the surface of the lipid droplets from pex3 Delta cells are on average shorter (C-16) than those (C-18) on the surface of lipid droplets from wild-type cells. We propose that the shift to shorter (C-18 -%26gt; C-16) acyl chains contributes to the reduced binding of alpha S to lipid droplets in pex3 Delta cells.

• 出版日期2013-8-23