Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei

作者：Festa Carmen; De Marino Simona; D' Auria Maria Valeria; Monti Maria Chiara; Bucci Mariarosaria; Vellecco Valentina; Debitus Cecile; Zampella Angela^*

来源：Tetrahedron, 2012, 68(13): 2851-2857.

DOI：10.1016/j.tet.2012.01.097

• Marine compounds
• Cyclopeptides
• Theonella swinhoei
• Anti-inflammatory activity

DCCC chromatography followed by HPLC purification on the polar extract of marine sponge Theonella swinhoei resulted in the isolation of five new cyclopeptides, perthamides G-K. The new structures, featuring unprecedented amino acid units, were determined by interpretation of extensive spectroscopic and spectrometric data (MS, H-1 and C-13 NMR, COSY, HSQC, HMBC, and ROESY). Pharmacological analysis demonstrated that these natural cyclopeptides are endowed with anti-inflammatory potential as assessed by their ability to reduce carrageenan-induced mouse paw oedema.

• 出版日期2012-4-1