Nanostructured CMOS Wireless Ultra-Wideband Label-Free PCR-Free DNA Analysis SoC

作者：Jafari Hamed Mazhab^*; Abdelhalim Karim; Soleymani Leyla; Sargent Edward H; Kelley Shana O; Genov Roman

来源：IEEE Journal of Solid-State Circuits, 2014, 49(5): 1223-1241.

DOI：10.1109/JSSC.2014.2312571

• Biosensor
• cyclic voltammetry
• DNA
• electrochemical sensor
• nano-structured electrodes
• ultra-wideband transmitter

A fully integrated 54-channel wireless fast-scan cyclic voltammetry DNA analysis SoC is presented. The microsystem includes 546 3D nanostructured and 54 2D gold DNA sensing microelectrodes as well as 54 pH sensors. Each channel consists of a chopper-stabilized current conveyer with dynamic element matching. It is utilized as the amperometric readout circuit with a linear resolution from 8.6 pA to 350 nA. The on-chip programmable waveform generator provides a wide range of user-controlled rate and amplitude parameters with a maximum scan range of 1.2 V, and scan rate ranging between 0.1 mV/sec to 300 V/sec. A digital ultra-wideband transmitter based on a delay line architecture provides wireless data communication with data rates of up to 50 Mb/sec while consuming 400 mu W. The 3 mm x 3 mm prototype fabricated in a 0.13 mu m standard CMOS technology has been validated in prostate cancer synthetic DNA detection with 10 aM label-free PCR-free detection limit. Each channel occupies an area of only 0.06 mm(2)and consumes 42 mu W of power from a 1.2 V supply.

• 出版日期2014-5