Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks

作者：Li Xiao Ling; Jones Matthew F; Subramanian Murugan; Lal Ashish^*

来源：FEBS LETTERS, 2014, 588(16): 2610-2615.

DOI：10.1016/j.febslet.2014.03.054

• Mutant p53
• microRNA
• miRNA
• Let-7
• miR-130b
• miR-128-2
• miR-155
• miR-223
• miR-27a
• miR-205
• Gain-of-function
• Invasion
• Metastasis
• Cancer

MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.

• 出版日期2014-8-19
• 单位NIH