AKAP5 signaling complexes: focal points and functional properties

作者：Guo Yanjing; Bo Tao; Zhou Xinli; Gao Ling; Wang Yong^*; Zhao Jiajun

来源：Neuroendocrinology Letters, 2015, 36(1): 7-14.

• AKAPs
• AKAP5
• AKAP5 signaling network
• anchoring properties
• binding proteins
• function properties

OBJECTIVE: Kinase Anchoring Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transduction. As a typical member, AKAP5 which consisting of three orthologues: bovine AKAP75, rodent AKAP150 and human AKAP79, is the best known model in the anchoring and targeting properties. It is shown that AKAP5 can bind beta 2-adrenergic receptor, which is a member of GPCR superfamily, and orchestrate the interactions of various protein kinases, protein phosphatases and cytoskeletal element. AKAP5 is originally identified as a component of the postsynaptic density in neurons and plays a vital role in modulating neuronal activities. Subsequently, the AKAP5 complexes are also detected in other tissues and participated in various processes.

• 出版日期2015
• 单位山东省立医院; 山东大学