Anti-allergic inflammatory effects of hepatocyte growth factor

作者：Ito Wataru; Takeda Masahide; Tanabe Masako; Kihara Junko; Kato Hikari; Chiba Takahito; Yamaguchi Kazutoshi; Ueki Shigeharu; Kanehiro Arihiko; Kayaba Hiroyuki; Chihara Junichi^*

来源：International Archives of Allergy and Immunology, 2008, 146: 82-87.

DOI：10.1159/000126067

• hepatocyte growth factor
• eosinophil
• allergy
• asthma

Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions.

• 出版日期2008