Preparation and characterization of polygalacturonic acid/rosmarinic acid membrane crosslinked by short chain hyaluronate for preventing postoperative abdominal adhesion

作者：Lee Ming Wei^*; Yang Tzi Peng; Peng Hsiu Hui; Chen Jia Wei

来源：Carbohydrate Polymers, 2012, 87(2): 1749-1755.

DOI：10.1016/j.carbpol.2011.09.088

• Polygalacturonic acid
• Hyaluronate
• Rosmarinic acid
• Korsmeyer-Peppas model
• Anti-adhesion

The most used materials for anti tissue adhesion after surgery are polymeric membranes. In this study, a short chain hyaluronate (sHA)-crosslinked polygalacturonic acid (PGA) membrane containing rosmarinic acid (PGA/RA membrane) was prepared and characterized. The in vitro dynamic release behavior of RA from the PGA membranes was analyzed. The profiles showed 70% of the total RA released from the membrane after 5 days. The best-fitting mathematical model for RA release from the PGA membrane was the Korsmeyer-Peppas model (r(2) = 0.996). In vivo evaluation of anti-postoperative tissue adhesion showed that use of a PGA/RA membrane reduced adhesion incidence by 90%. Anti-inflammatory analysis results showed that on the third day following surgery, the number of neutrophils and macrophages in the PGA-treated group (without RA) was 2.1 and 2.4 times that of the PGA/RA-treated group, respectively. Thus, the PGA/RA membrane developed in this study has anti-postoperative tissue adhesion and anti-inflammatory capabilities.

• 出版日期2012-1-15