Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

作者：Mathiyazhakan Malathi; Yang Yuanxiang; Liu Yibo; Zhu Caigang; Liu Quan; Ohl Claus Dieter; Tam Kam Chiu; Gao Yu; Xu Chenjie^*

来源：Colloids and Surfaces B: Biointerfaces , 2015, 126: 569-574.

DOI：10.1016/j.colsurfb.2014.11.019

• Exogenous stimuli-responsive nanoparticles
• Thermal-responsive liposome
• Gold nanoparticles
• Drug delivery
• Controlled release
• Microbubble cavitation

Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.

• 出版日期2015-2-1
• 单位南阳理工学院