Development and structure of a novel barrier membrane composed of drug-loaded poly(lactic-co-glycolic acid) particles for guided bone regeneration

作者：Son Jun Sik; Kim Su Gwan^*; Jin Seung Chan; Piao Zheng Gang; Lee Sook Young; Oh Ji Su; Kim Chun Sung; Kim Byung Hoon; Jeong Mi Ae

来源：Biotechnology Letters, 2012, 34(4): 779-787.

DOI：10.1007/s10529-011-0819-x

• Bone regeneration
• Dexamethasone
• Guided bone regeneration
• Membrane
• Poly(lactic-co-glycolic acid)

A novel barrier membrane composed of poly(lactic-co-glycolic acid) particles loaded with dexamethasone (DEX) as a bioactive molecule was produced via a modified nanoprecipitation method without any mixing. The particle membranes had a bilayer structure: one side was smooth and had a compact surface that was connected to larger particles, while the opposite side was rough, porous and connected to smaller particles. Additionally, a cross-section of the particle membrane had a porous structure with nano and micro sized irregular pores. Process optimization revealed that NaCl concentration in the water phase, with acetone as solvent and water as a non-solvent, played critical roles in determining the properties of the particle membranes, such as DEX encapsulation efficiency, thickness and surface morphologies of the particle membranes. A novel barrier membrane containing DEX using polymer particle drug capture technology has been successfully developed.

• 出版日期2012-4