Anti-Inflammatory Effects of Licochalcone A on IL-1 beta-Stimulated Human Osteoarthritis Chondrocytes

作者：Jia, Tao^*; Qiao, Jiutao; Guan, Dehong; Chen, Tianxin

来源：Inflammation, 2017, 40(6): 1894-1902.

DOI：10.1007/s10753-017-0630-5

• osteoarthritis chondrocyte
• IL-1 beta
• NF-kappa B
• Nrf2

Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), has been reported to have anti-inflammatory activity. In this study, we evaluated the anti-inflammatory effects of Lico A on IL-1 beta-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that Lico A treatment significantly inhibited PGE2 and NO production induced by IL-1 beta. IL-1 beta-induced iNOS and COX-2 expression were also inhibited by Lico A. Lico A inhibited MMP1, MMP3, and MMP13 production in IL-1 beta-stimulated chondrocytes. Lico A also inhibited IL-1 beta-induced phosphorylation of NF-kappa B p65 and I kappa B alpha. Meanwhile, Lico A was found to upregulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of Lico A. In conclusion, our results suggested that Lico A showed anti-inflammatory effects in IL-1 beta-stimulated chondrocytes by activating Nrf2 signaling pathway.

• 出版日期2017-12
• 单位哈尔滨医科大学