Comparative Study of PVC-Free All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for the Determination of Dapoxetine Hydrochloride in Pharmaceutical Formulation

作者：Aziz Azza; Khamees Nesrin; Mohamed Tagreed Abdel Fattah; Derar Abeer Rashad^*

来源：Journal of AOAC International, 2016, 99(6): 1499-1504.

DOI：10.5740/jaoacint.16-0089

The potentiometric response characteristics and analytical applications of a poly(vinyl chloride) (PVC)-free all-solid-state ion-selective electrode for dapoxetine hydrochloride (DAP) are examined. The Nernstian response of the electrode was evaluated by comparison with PVC-based liquid membrane and carbon paste electrodes. The PVC-free electrode is prepared by direct incorporation of dapoxetine-tetraphenyl borate (DAP-TPB) as a sensing element into a commercial nail varnish containing cellulose acetate propionate. The composite was applied onto a 3 mm diameter graphite disk electrode. The electrode exhibited a Nernstian slope of 56.0 mV/decade in the concentration range of 1x10(-4) to 1x10(-2) mol/L with an LOD of 2 x 10(-5) mol/L. The electrode is independent of pH in the range of 2 to 6 and showed good selectivity for DAP with respect to a large number of inorganic cations and amino acids. Comparable Nernstian slope, sensitivity, pH range, and selectivity pattern were obtained with a PVC membrane and a carbon paste incorporating DAP-TPB as a sensing element and dioctylphthalate as a solvent mediator. The electrodes were used for the determination of DAP in pure solution and in tablets without extraction with high accuracy and precision (RSD <= 2%). The nail varnish solid-state electrode is simple, economical, and rapid when compared with PVC membrane and carbon paste electrodes.

• 出版日期2016-12