Antituberculosis drugs degradation by UV-based advanced oxidation processes

作者：Stets Sandra; do Amaral Bianca; Schneider Jessica Tamara; de Barros Ivan Ricardo; de Liz Marcus Vinicius; Ribeiro Ronny Rocha; Nagata Noemi; Peralta Zamora Patricio

来源：Journal of Photochemistry and Photobiology A: Chemistry , 2018, 353: 26-33.

DOI：10.1016/j.jphotochem.2017.11.006

• Rifampicin
• Isoniazid
• Pharmaceuticals degradation
• Radical scavenging

Several advanced oxidation processes (AOPs) were investigated for the degradation of isoniazid (INH) and rifampicin (RIF) in aqueous solution: TiO2 and ZnO heterogeneous photocatalysis and homogeneous and heterogeneous UV-A photo-Fenton processes. Under optimized conditions (pH 6.0 and 500 mg L-1 of photocatalyst) the UV-ATiO(2)-photocatalysis removed approximately 90% of INH and 60% of RIF at 60 min. Under similar experimental conditions, the degradation efficiency of ZnO was significantly lower to INH. The low-cost UV-A homogeneous photo-Fenton process removed 70% of INH and 80% of RIF at 60 min. Photo-Fenton process using iron-immobilized in chitosan beads showed lower degradation efficiency (7% to INH and 50% to RIF) probably due to low iron availability in the catalyst surface. A radical scavenging assay was performed to investigate the effect of free radicals (hydroxyl radical ((OH)-O-center dot), electron vacancy (hole, h(+)), superoxide radical anions (O-2(center dot-), and singlet oxygen (O-1(2))) on INH and RIF degradation during TiO2/UV-A photocatalysis. The two drugs have distinct degradation mechanisms, while RIF is degraded by H+, INH suffers influence of various active species. The TiO2/UV-A photocatalysis was employed to degrade INH/RIF residue.

• 出版日期2018-2-15