New sesquiterpenoids from Petasites japonicus and Petasites tricholobus

作者:Hai, Ping; Gao, Yuan; Xiao, Chun-Gui; Jiang, Xian-Jun; Li, Xiang-Mei; Yang, Wan-Qiu; Li, Rong-Tao; Wang, Fei*
来源:Phytochemistry Letters, 2018, 23: 41-45.
DOI:10.1016/j.phytol.2017.10.008

摘要

Phytochemical investigation of the whole plants of Petasites japonicus and Petasites tricholobus led to the isolation of five new bakkenolide-type sesquiterpenoids, bakkenolide-Ib (1), bakkenolide-IIb (2), bakkenolide-IIIb (3), bakkenolide-IVb (4), and bakkenolide-Vb (5), and a new eremophilane-type norsesquiterpenoid, petasindiol (6). Their structures were elucidated by NMR and HRESIMS analyses. Petasindiol (6) represented the first example of 15-noreremophilane sesquiterpenoid from the genus Petasites.