An atom efficient, green synthesis of 2-pyrazoline derivatives under solvent-free conditions using grinding technique

作者：Zangade Sainath B; Mokle Shyam S; Shinde Avinash T; Vibhute Yeshwant B^*

来源：Green Chemistry Letters and Reviews, 2013, 6(2): 123-127.

DOI：10.1080/17518253.2012.713123

• 2-hydroxychalcones
• 2-pyrazolines
• solvent free
• grinding technique
• green chemistry

A simple, rapid, efficient, and environmentally benign procedure for synthesis of 2-pyrazoline derivatives has been achieved by reacting 2-hydroxychalcones with hydrazine hydrate under solvent-free grinding technique. The short reaction time, cleaner reaction, easy workup, higher yields, and mild reaction conditions make this protocol practical and economically attractive in comparison with the classical reaction.
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• 出版日期2013-6-1