Farnesyl protein transferase inhibitory components of Polygonum multiflorum

作者：Kwon Byoung Mog; Kim Sung Hoon; Baek Nam In; Lee Sa Im; Kim Eun Jeong; Yang Jae Heon; Chae Byeong Suk; Lee Jae Hyeok; Park Hee Wook; Park Jeong Suk; Kim Dae Keun^*

来源：Archives of Pharmacal Research, 2009, 32(4): 495-499.

DOI：10.1007/s12272-009-1403-y

• Polygonum multiflorum
• Polygonaceae
• Anthraquinone glycosides
• FPTase

The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.

• 出版日期2009-4