A retrospective analysis of therapeutic responses to two distinct corticosteroids in 259 children with acute primary idiopathic thrombocytopenic purpura

作者：Su, Yongchun^*; Xu, Hongzhen; Xu, Youhua; Yu, Jie; Dai, Bitao; Xian, Ying; Xiao, Jianwen

来源：Hematology, 2009, 14(5): 286-289.

DOI：10.1179/102453309X12473408860343

• ITP
• thrombocytopenia
• children
• corticosteroids

Objective: To analyze the responses of pediatric patients with newly-diagnosed acute primary idiopathic thrombocytopenic purpura (ITP) to two distinct corticosteroids. @@@ Methods: We retrospectively reviewed a cohort of 259 patients with acute ITP diagnosed between 2004 and 2008. Specifically, we compared response rates and adverse effects in patients treated with methylprednisolone or dexamethasone. @@@ Results: Corticosteroids were used as the first-line treatment in all patients with an initial response rate of 96.5%. Choice of the intravenous corticosteroid for treatment did not affect the outcome of patients. The time platelet count maintained at a normal level showed no statistical difference between patients administered with methylprednisolone or dexamethasone. Only minor adverse effects were observed in both groups of patients. @@@ Conclusions: Both corticosteroids yielded similarly high response rates and minor adverse effects in ITP patients. This should be taken into account when choosing the treatment regimen for children with acute ITP.

• 出版日期2009-10
• 单位重庆医科大学