Assessment of the predictive value of serum progesterone levels on early pregnancy prognosis in spontaneous twin gestations: A prospective study

作者：Goktolga Umit^*; Gungor Sadettin; Ceyhan Seyit Temel; Keskin Ugur; Fidan Ulas; Gezginc Kazim; Baser Iskender

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2008, 137(2): 185-188.

DOI：10.1016/j.ejogrb.2007.10.016

• spontaneous twin pregnancy
• progesterone
• predictive value

Objectives: The aim of this study was to assess the predictive value of serum progesterone levels in early pregnancy prognosis in spontaneous dichorionic-diamniotic twin gestations.
Study design: This study was carried out among 38 spontaneous dichorionic-diamniotic twin gestations between January 2003 and June 2005 in the Department of Obstetrics and Gynaecology at the Gulhane Military Medical Academy. Serum progesterone levels were measured at 7 and 10 weeks' gestation and pregnancies were followed until 14 gestational weeks by ultrasound examination.
Results: We found that a progesterone level of 58 nmol/l in the 7th gestational week and of 51 ng/ml at 10 gestational weeks has a predictive value for viable intrauterine twin pregnancies with 83% sensitivity and 69% specificity and 83% sensitivity and 84% specificity, respectively.
Conclusion: Progesterone levels in the early gestational weeks may be a biochemical marker for the prediction of a twin pregnancy outcome and may reduce the number of ultrasound examinations.

• 出版日期2008-4
• 单位中国人民解放军军事医学科学院