Development of a DNA-damaging ferrocene amino acid

作者：Cooper Daniel C; Yennie Craig J; Morin Jesse B; Delaney Sarah; Suggs J William^*

来源：Journal of Organometallic Chemistry, 2011, 696(19): 3058-3061.

DOI：10.1016/j.jorganchem.2011.05.018

• Ferrocene
• Nuclease
• Proton coupled electron transfer
• DNA damage

The oxygen-sensitive ferrocenylacetic acid moiety was incorporated in a water-soluble DNA-damaging agent via the synthon 1,1'-ferrocenediacetic acid anhydride. The extent of plasmid nicking was pH-dependent, with complete cleavage at pH 5.5. The nicking was indiscriminate and required O(2), implicating reduced oxygen species as the actual damaging agent.

• 出版日期2011-9-15