Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus

作者：Zhao, Dian-dian; Jiao, Pei-lin; Yu, Jing-jia; Wang, Xiao-jing; Zhao, Lin; Xuan, Yan; Sun, Li-hao; Tao, Bei; Wang, Wei-qing; Ning, Guang; Liu, Jian-min; Zhao, Hong-yan^*

来源：International Journal of Endocrinology, 2016, 2016: 2528956.

DOI：10.1155/2016/2528956

• RENAL-FUNCTION
• HYPERURICEMIA
• OSTEOPOROSIS
• WOMEN
• RISK

Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p < 0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r = 0.322), body mass index (BMI) (r = 0.331), Ca (r = 0.179), and Cr (r = 0.239) (p < 0.001) and were also positively associated with the concentrations of PTH (r = 0.10, p < 0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31-0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.

• 出版日期2016
• 单位上海交通大学; 上海市闵行区中心医院