Mitochondrial fission augments capsaicin-induced axonal degeneration

作者：Chiang Hao; Ohno Nobuhiko; Hsieh Yu Lin; Mahad Don J; Kikuchi Shin; Komuro Hitoshi; Hsieh Sung Tsang^*; Trapp Bruce D

来源：Acta Neuropathologica, 2015, 129(1): 81-96.

DOI：10.1007/s00401-014-1354-3

• Mitochondria
• Axonal swellings
• Capsaicin
• Miro
• Drp1

Capsaicin, an agonist of transient receptor potential vanilloid receptor 1, induces axonal degeneration of peripheral sensory nerves and is commonly used to treat painful sensory neuropathies. In this study, we investigated the role of mitochondrial dynamics in capsaicin-induced axonal degeneration. In capsaicin-treated rodent sensory axons, axonal swellings, decreased mitochondrial stationary site length and reduced mitochondrial transport preceded axonal degeneration. Increased axoplasmic Ca2+ mediated the alterations in mitochondrial length and transport. While sustaining mitochondrial transport did not reduce axonal swellings in capsaicin-treated axons, preventing mitochondrial fission by overexpression of mutant dynamin-related protein 1 increased mitochondrial length, retained mitochondrial membrane potentials and reduced axonal loss upon capsaicin treatment. These results establish that mitochondrial stationary site size significantly affects axonal integrity and suggest that inhibition of Ca2+-dependent mitochondrial fission facilitates mitochondrial function and axonal survival following activation of axonal cationic channels.

• 出版日期2015-1